Researcher Dr. Eric Kandel, whose contributions at Columbia University include the molecular basis of memory and a team, discovered therapeutic interventions like exercise help reduce age-related memory loss. “We were astonished that not only did this improve the mice’s performance on the memory tests, but their performance was comparable to that of young mice,” said Dr. Pavlopoulos.“The fact that we were able to reverse age-related memory loss in mice is very encouraging,” said Dr. Kandel.
They examined proteins in human cells in the hippocampus region that contribute to memory functions. These proteins, RbAp48 and the PKA-CREB1-CBP, are valid targets for therapeutic intervention.
Agents that enhance this pathway have already been shown to improve age-related hippocampus dysfunction in rodents. “But the broader point is that to develop effective interventions, you first have to find the right target. Now we have a good target... we have a way to screen therapies that might be effective, be they pharmaceuticals, nutraceuticals, or physical and cognitive exercises.”
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